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Original Article
Samaneh Tokhanbigli ORCID, Helia Alavifard ORCID, Hamid Asadzadeh Aghdaei, Mohammad Reza Zali, Kaveh Baghaei* ORCID
Bioimpacts. 2023;13(4): 333-346. doi: 10.34172/bi.2022.24209
PMCID: PMC10460770     PMID: 37645031     Scopus ID: 85154024997    
Combining LY6E loaded DC therapy with pioglitazone improved the DC therapy effect for colorectal cancer treatment. LY6E pulsed DCs excites the CD8 positive immune responses against colorectal models. Pioglitazone inhibits IL-6 axis and formation of CRC cell lines proliferation through IL-6/STAT3 by influencing the immunosuppressive feature of the tumor microenvironment.


As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
Acceptance rate: 24% 
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